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Zoledronate

n.c.a. 177Lu-DOTA-Zoledronate / 68Ga-DOTA-Zoledronate

DOTA-Zoledronate is a next generation agent for bone Targeted Radionuclide Therapy and diagnostics in patients suffering from bone metastases. DOTA-Zoledronate specifically targets cancerous bone lesions and, when radiolabeled with therapeutic or diagnostic radioisotopes, has shown high potential for PET-Imaging and radionuclide therapy.

This novel bisphosphonate derivative is attractive for tagging of beta-emitting n.c.a. Lutetium-177 (EndolucinBeta®) as well as the generator derived PET-radionuclide Gallium-68. Due to its versatile properties for radiolabeling, DOTA-Zoledronate is also a promising precursor for the development of other future-oriented radionuclide therapeutic concepts in the field of Precision Oncology, such as targeted alpha particle therapy.